PITX2 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP14021a
Background:
This gene encodes a member of the RIEG/PITX homeoboxfamily, which is in the bicoid class of homeodomain proteins. Theencoded protein acts as a transcription factor and regulatesprocollagen lysyl hydroxylase gene expression. This protein plays arole in the terminal differentiation of somatotroph and lactotrophcell phenotypes, is involved in the development of the eye, toothand abdominal organs, and acts as a transcriptional regulatorinvolved in basal and hormone-regulated activity of prolactin.Mutations in this gene are associated with Axenfeld-Riegersyndrome, iridogoniodysgenesis syndrome, and sporadic cases ofPeters anomaly. A similar protein in other vertebrates is involvedin the determination of left-right asymmetry during development.Alternatively spliced transcript variants encoding distinctisoforms have been described.
Other Names:
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14021a was selected from the N-term region of PITX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PITX2 (HGNC:9005)
Gene ID: 5308
Primary Accession: Q99697
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the RIEG/PITX homeoboxfamily, which is in the bicoid class of homeodomain proteins. Theencoded protein acts as a transcription factor and regulatesprocollagen lysyl hydroxylase gene expression. This protein plays arole in the terminal differentiation of somatotroph and lactotrophcell phenotypes, is involved in the development of the eye, toothand abdominal organs, and acts as a transcriptional regulatorinvolved in basal and hormone-regulated activity of prolactin.Mutations in this gene are associated with Axenfeld-Riegersyndrome, iridogoniodysgenesis syndrome, and sporadic cases ofPeters anomaly. A similar protein in other vertebrates is involvedin the determination of left-right asymmetry during development.Alternatively spliced transcript variants encoding distinctisoforms have been described.
Other Names:
Pituitary homeobox 2, ALL1-responsive protein ARP1, Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, RIEG bicoid-related homeobox transcription factor, Solurshin, PITX2, ARP1, RGS, RIEG, RIEG1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14021a was selected from the N-term region of PITX2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PITX2 (HGNC:9005)
Gene ID: 5308
Primary Accession: Q99697
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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