PIWI-L1 polyclonal, anti-human, mouse, rat

Protein Family: Translation Factors

Pathway and Disease: Development and Behavior, Folding, Sorting and Degradation, Replication and Repair, Translation

Description:
PIWI-L1 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L1 is thought to play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells as removing PIWI-L1 protein from single germline stem cells significantly decreases the rate of their division. Recent studies have shown that overexpression of PIWI-L1 (as well as other PIWI-like proteins) are potential biomarkers for colon and other cancers.

Alternate Names: PIWI-L1, PIWI-like 1, PIWIL1, PIWI, MIWI, HIWI

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; IHC: 1:100-1:500

Accession No.: AAK69348

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PIWI-L1.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.