PIWIL1 polyclonal, anti-human, mouse, rat

Protein Family: Translation Factors

Pathway and Disease: Development and Behavior, Folding, Sorting and Degradation, Replication and Repair, Translation

Description:
Piwi-like protein 1 (PIWIL1) plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL1 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governing the methylation and subsequent repression of transposons. PIWIL1 binds pi RNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism. PIWIL1 is also involved in the formation of chromatoid bodies and is required for some piRNAs stability.

Alternate Names: Piwi-like protein 1, PIWIL1, HIWI, PIWI-L1

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: Q96J94

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PIWIL1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.