PIWIL4 polyclonal, anti-human

Protein Family: Chaperones and Folding Catalysts

Pathway and Disease: Development and Behavior

Description:
Piwi-like protein 4 (PIWIL4) plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. PIWIL4 acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. PIWIL4 directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements.

Alternate Names: Piwi-like protein 4, PIWIL4, HIWI2, PIWI

Application Notes: E: 1:10,000-1:50,000; WB: 1:250-1:1,000

Accession No.: Q7Z3Z4

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human PIWIL4.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.