PKC θ (phospho Ser676) Polyclonal Antibody

Background:
protein kinase C theta(PRKCQ) Homo sapiens Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008],

Alternative Names:
PRKCQ, PRKCT, Protein kinase C theta type, nPKC-theta

Immunogen: The antiserum was produced against synthesized peptide derived from human PKC thet around the phosphorylation site of Ser676. AA range:643-692

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 82

GeneID: PRKCQ

Storage: -20°C/1 year

NOTE: For Research Use Only