PKCγ polyclonal, anti-human, mouse, rat

Background:
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes including conventional (c) PKC isoforms (α, βI, βII and γ) and novel (n) PKC isoforms (δ, ε, ζ, η and θ). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of nPKC δ and ε are independent of Ca2+.

Alternative Name:
PKC-gamma, PRKCG, PKCG, KPCG, MGC57564, OTTHUMP00000067291, PKC-gamma, PKCC, PKCG, PRKCG, Protein kinase C gamma, Protein kinase C gamma polypeptide, Protein kinase C gamma type, Protein kinase C, gamma, SCA 14, SCA14,

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200

Specificity: PKCγ polyclonal antibody detects endogenous levels of PKCγ protein.

Immunogen:
Synthetic peptide within Human PKC gamma aa 350-450.

MW: 78 kDa

Swiss-Prot: P05129(Human) P63318(Mouse) P63319(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.