PKLR polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7701
Background:
In mammals, four different isoenzymes exist for pyruvate kinase. Based on their tissue distribution, the isoenzymes are designated L-type (for predominant expression in the liver), R-type (for predominant expression in red blood cells), M1-type (for predominant expression in muscle, brain and heart) and M2-type (for predominant expression in fetal tissues). Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKLR (pyruvate kinase, liver and RBC) gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The R-type isoform, also known as RPK (R-type pyruvate kinase), exists as a tetramer and, when functioning improperly, can result in chronic/hereditary nonspherocytic hemolytic anemia (CNSHA/HNSHA) or pyruvate kinase hyperactivity (also called high red cell ATP syndrome). The L-type isoform, alternatively known as PKL (pyruvate kinase L-type), also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young (MODY).
Alternative Name:
EC 2.7.1.40, KPYR_HUMAN, L-PK, Pk-1, PK1, PKL, Pklg, Pklr, PKR, PKRL, Pyruvate kinase 1, Pyruvate kinase isozymes R/L, Pyruvate kinase liver and blood cell, Pyruvate kinase liver and RBC, Pyruvate kinase liver and red blood cell, Pyruvate kinase liver type, Pyruvate kinase type L, Pyruvate kinase, red cell type, R type/L type pyruvate kinase, R-PK, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, RPK,
Application Dilution: WB: 1:500 - 1:2000
Specificity: PKLR polyclonal antibody detects endogenous levels of PKLR protein.
Immunogen:
Recombinant full length Human PKLR.
MW: ~ 62 kDa
Swis Prot.: P30613
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
In mammals, four different isoenzymes exist for pyruvate kinase. Based on their tissue distribution, the isoenzymes are designated L-type (for predominant expression in the liver), R-type (for predominant expression in red blood cells), M1-type (for predominant expression in muscle, brain and heart) and M2-type (for predominant expression in fetal tissues). Pyruvate kinases are responsible for catalyzing the final step in glycolysis: the conversion of phosphoenolpyruvate to pyruvate with the coinciding generation of ATP. The PKLR (pyruvate kinase, liver and RBC) gene encodes the L- and R-type isoenzymes through alternative splicing events under the control of different promoters. The R-type isoform, also known as RPK (R-type pyruvate kinase), exists as a tetramer and, when functioning improperly, can result in chronic/hereditary nonspherocytic hemolytic anemia (CNSHA/HNSHA) or pyruvate kinase hyperactivity (also called high red cell ATP syndrome). The L-type isoform, alternatively known as PKL (pyruvate kinase L-type), also exists as a tetramer and is upregulated by glucose with implications in maturity-onset diabetes of the young (MODY).
Alternative Name:
EC 2.7.1.40, KPYR_HUMAN, L-PK, Pk-1, PK1, PKL, Pklg, Pklr, PKR, PKRL, Pyruvate kinase 1, Pyruvate kinase isozymes R/L, Pyruvate kinase liver and blood cell, Pyruvate kinase liver and RBC, Pyruvate kinase liver and red blood cell, Pyruvate kinase liver type, Pyruvate kinase type L, Pyruvate kinase, red cell type, R type/L type pyruvate kinase, R-PK, R-type/L-type pyruvate kinase, Red cell/liver pyruvate kinase, RPK,
Application Dilution: WB: 1:500 - 1:2000
Specificity: PKLR polyclonal antibody detects endogenous levels of PKLR protein.
Immunogen:
Recombinant full length Human PKLR.
MW: ~ 62 kDa
Swis Prot.: P30613
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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