PKLR Polyclonal Antibody

Background:
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
PKLR, PK1, PKL, PKR, PKRL, RPK

Immunogen: Recombinant fusion protein of human PKLR (NP_000289.1).

Swissprot: P30613
Gene ID: 5313

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.