PKN1 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Synonyms: DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1

Cellular Location: Cell membrane Cleavage furrow Cytoplasm Endosome Midbody Nucleus Peripheral membrane protein

Immunogen:
Recombinant protein of human PKN1

Gene Symbol: PKN1

Gene ID: 5585

Swiss prot: Q16512

Calculated MW: 104kDa

Recommended dilution:
WB 1:500-1000, IHC 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.