PLA2G4A polyclonal, anti-human, mouse, rat

Background:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Synonyms: PLA2G4, cPLA2-alpha

Cellular Location: Cytoplasm

Immunogen:
Recombinant protein of human PLA2G4A

Gene Symbol: PLA2G4A

Gene ID: 5321

Swiss prot: P47712

Calculated MW: 85kDa

Recommended dilution:
WB 1:500-2000, IHC 1:25-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.