PLAC1 polyclonal, anti-human

Protein Family: Receptors and Channels

Pathway and Disease: Cancers, Cell Growth and Death, Signaling Molecules and Interaction

Description:
PLAC1 was initially identified as a protein expressed specifically in the placenta and other cells derived from the trophoblast lineage during embryonic development, but has also been found to be expressed ectopically in a wide range of human malignancies, particularly breast cancers. PLAC1 is a membrane-associated protein that is thought to serve a receptor-like function modulating cell-cell or ligand receptor interactions unique to the maternal-placental interface. Decreased expression of PLAC1 is associated with decreased expression of cyclin D1 and reduced expression of AKT kinase, which, combined with the fact that PLAC1 is expressed on the surface of cancer cells, suggests that PLAC1 may be an effective candidate for immunotherapeutic treatments of cancer.

Alternate Names: PLAC1, Placenta-specific protein 1, CT92

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; ICC: 1:100-1:500

Accession No.: NP_068568

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLAC1.

Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.