PLAC3 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254370
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Alternate Names: PLAC3, Placenta-specific protein 3, Pappalysin 2, pregnancy-associated plasma protein A2, PAPP-A2, PAPPA2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_064714
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human PLAC3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Alternate Names: PLAC3, Placenta-specific protein 3, Pappalysin 2, pregnancy-associated plasma protein A2, PAPP-A2, PAPPA2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_064714
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human PLAC3.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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