Plasminogen Activator Inhibitor-1 (PAI-1) (clone 3H3), anti-human
€290.00
In stock
SKU
IMD-21070
Monoclonal Antibody against Human PAI-1
Application: ELISA
Host: Mouse
INTRODUCTION
Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis [1,2]. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue [3]. It is normally present at low levels in plasma and tissue, but its expression and release are increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome [4]. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases [5-8]. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
IMMUNOGEN: Recombinant human PAI-1 expressed in E.coli.
SPECIFICITY: The antibody detects human PAI-1.
PURIFICATION: Protein G affinity PURIFICATION:
FORMULATION: Liquid in phosphate-buffered saline (PBS).
STORAGE:
Store at –20°C for less than one week. For long-term STORAGE: , aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
APPLICATION/USAGE
This antibody can be used as a capture antibody in a human PAI-1 ELISA in combination with polyclonal anti-human PAI-1 antibody as detection antibody.
REFERENCES
Lijnen HR, et al. (1995) Baillieres Clin Haematol. 8: 277–290
Dellas C, et al. (2005) Thromb Haemost. 2005; 93: 631–640
Binder BR, et al. (2002) News Physiol Sci 17:56-61
Vague P, et al. (1986) Metabolism. 35: 250–253
Sobel Be, et al. (2003) Arterioscler Thromb Vasc Biol. 23: 1979–1989
Eitzman DT, et al. (1996) J Clin Invest. 97(1):232-7
Gils A, et al. (2004) Thromb. Haemost. 91 (3): 425–37
Cale JM, Lawrence DA. (2007) Curr Drug Targets. 8(9):971-81
Application: ELISA
Host: Mouse
INTRODUCTION
Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of tissue-type and urokinase-type plasminogen activator, playing a major role in fibrinolysis [1,2]. PAI-1 is mainly produced by the endothelium, but is also secreted by other tissue types, such as adipose tissue [3]. It is normally present at low levels in plasma and tissue, but its expression and release are increased in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome [4]. PAI-1 is also involved in the pathophysiology of renal, pulmonary, cardiovascular, and metabolic diseases [5-8]. Elevated local or systemic PAI-1 can also exacerbate such pathologic conditions.
IMMUNOGEN: Recombinant human PAI-1 expressed in E.coli.
SPECIFICITY: The antibody detects human PAI-1.
PURIFICATION: Protein G affinity PURIFICATION:
FORMULATION: Liquid in phosphate-buffered saline (PBS).
STORAGE:
Store at –20°C for less than one week. For long-term STORAGE: , aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
APPLICATION/USAGE
This antibody can be used as a capture antibody in a human PAI-1 ELISA in combination with polyclonal anti-human PAI-1 antibody as detection antibody.
REFERENCES
Lijnen HR, et al. (1995) Baillieres Clin Haematol. 8: 277–290
Dellas C, et al. (2005) Thromb Haemost. 2005; 93: 631–640
Binder BR, et al. (2002) News Physiol Sci 17:56-61
Vague P, et al. (1986) Metabolism. 35: 250–253
Sobel Be, et al. (2003) Arterioscler Thromb Vasc Biol. 23: 1979–1989
Eitzman DT, et al. (1996) J Clin Invest. 97(1):232-7
Gils A, et al. (2004) Thromb. Haemost. 91 (3): 425–37
Cale JM, Lawrence DA. (2007) Curr Drug Targets. 8(9):971-81
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