PLAUR Polyclonal Antibody

Background:
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.

Research Area: Cardiovascular, Immunology, Cancer

Synonyms:
CD 87, CD87, CD87 antigen, MO 3, MO3, Monocyte activation antigen Mo3, Plasminogen activator receptor urokinase, Plasminogen activator urokinase receptor, PLAUR, U PAR, u plasminogen activator receptor, U-PAR, u-plasminogen activator receptor form 2, UPA receptor, uPAR, UPAR, Urinary plasminogen activator receptor, URKR, Urokinase plasminogen activator receptor, Urokinase plasminogen activator surface receptor, urokinase-type plasminogen activator (uPA) receptor

Immunogen: Recombinant Human Urokinase plasminogen activator surface receptor protein

Swissprot: Q03405
Gene ID: 5329

Purification Method: Antigen Affinity Purification

Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3

Concentration: 0.85 mg/mL
Dilution: IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.