PLC γ2 (phospho-Y759) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64003
Background:
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptormediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol fromphosphatidylinositol 4,5-bisphosphate.There are manymammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC γ2 associateswith several tyrosine-phosphorylated proteins(Syk, SLP-76,Lyn, linker for activation of T cells(LAT) and the FcR γ chain),which bind to its C-terminal SH2 domain. PLC γ1 associateswith Syk in B cells, but PLC γ2 does not associatewith Sykin platelets. The C-terminal SH2 domain isinvolved in the regulation of PLC γ2. In addition, Btkcan induce PLC γ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Alternative Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, EC=3.1.4.11, Phosphoinositide phospholipase C-gamma-2 Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Application Dilution: WB: 1:500~1:1000
Specificity: p-PLC γ2 (Y759) polyclonal antibody detects endogenous levels of PLC γ2 protein only when phosphorylated at Tyr759.
Immunogen:
A synthetic peptide corresponding to residues in Human PLC γ2 around the phosphorylation site of Tyrosine 759.
MW: ~ 148 kDa
Swis Prot.: P16885
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptormediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol fromphosphatidylinositol 4,5-bisphosphate.There are manymammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC ε. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC γ2 associateswith several tyrosine-phosphorylated proteins(Syk, SLP-76,Lyn, linker for activation of T cells(LAT) and the FcR γ chain),which bind to its C-terminal SH2 domain. PLC γ1 associateswith Syk in B cells, but PLC γ2 does not associatewith Sykin platelets. The C-terminal SH2 domain isinvolved in the regulation of PLC γ2. In addition, Btkcan induce PLC γ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Alternative Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, EC=3.1.4.11, Phosphoinositide phospholipase C-gamma-2 Phospholipase C-IV, PLC-IV, Phospholipase C-gamma-2, PLC-gamma-2
Application Dilution: WB: 1:500~1:1000
Specificity: p-PLC γ2 (Y759) polyclonal antibody detects endogenous levels of PLC γ2 protein only when phosphorylated at Tyr759.
Immunogen:
A synthetic peptide corresponding to residues in Human PLC γ2 around the phosphorylation site of Tyrosine 759.
MW: ~ 148 kDa
Swis Prot.: P16885
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review