PLCG1 antibody (clone 2A2), anti-human
€435.00
In stock
SKU
AC-AT3335a
Catalog Number: AC-AT3335a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, IF, E
Request Information AC-AT3335a">Request Information
Background:
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1, PLC1
Antigen Type:
Recombinant Protein
Gene Name: PLCG1 (HGNC:9065)
Gene ID: 5335
NCBI Accession: NP_002651.2;NP_877963.1
Primary Accession: P19174
Other Accession: NM_002660
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Other Names:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1, PLC1
Antigen Type:
Recombinant Protein
Gene Name: PLCG1 (HGNC:9065)
Gene ID: 5335
NCBI Accession: NP_002651.2;NP_877963.1
Primary Accession: P19174
Other Accession: NM_002660
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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