Plectin polyclonal, anti-human, mouse, rat

Background:
Plectin is an abundant cytoskeletal protein that is involved in cytoplasm stabilization. Plectin has been shown to crosslink intermediate filaments to microtubules and microfilaments, and to anchor intermediate filaments to the plasma and nuclear membranes. Plectin binds both Lamin B and vimentin, and this binding is regulated by a variety of protein kinases. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions. Plectin is also a substrate for p34cdc2 kinase. Several alternative splice isoforms of plectin are known to exist. Mutations in human plectin are known to cause epidermolysis bullosa simplex with muscular dystrophy (EBS-MD).

Alternative Name:
PCN, PLTN, HD1, PLEC, EBS1, EBSO, HD1, Hemidesmosomal protein 1, PCN, pleC, PLEC, PLEC1, PLEC1b, Plectin 1, Plectin 1 intermediate filament binding protein 500kDa, Plectin 6, Plectin, Plectin-1, PLTN,

Application Dilution:
WB:1:1,000
IHC:1:100-1:500

Specificity: Plectin polyclonal antibody detects endogenous levels of Plectin protein.

Immunogen:
recombinant protein

MW: 531 kDa

Swiss-Prot: Q15149(Human) Q9QXS1(Mouse) P30427(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.