PLEKHG6 Polyclonal Antibody

Background:
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Research Area: Cancer, Cell Biology, Signal Transduction

Synonyms:
FLJ10665, MGC126315, MGC126353, MGC126354, Myosin interacting guanine nucleotide exchange factor, PH domain containing family G member 6, Pleckstrin homology domain containing family G (with RhoGef domain) member 6, Pleckstrin homology domain-containing family G member 6, PLEKHG6

Immunogen: Recombinant protein of human PLEKHG6

Swissprot: Q3KR16
Gene Accession: BC105961

Calculated MW: 89 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.1 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.