PLGF polyclonal, anti-human

Protein Family: CAM Ligands, Cytokines

Pathway and Disease: Cancers, Cell Communication, Signal Transduction, Signaling Molecules and Interaction

Description:
Placenta growth factor (PLGF or PIGF) is a dimeric glycoprotein showing the highest degree of sequence similarity to the vascular endothial growth factor. Alternative splicing of the PLGF primary transcript gives rise to three forms named PIGF-1, 2 and 3, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. PLGF is active in angiogenesis and endothelial cell growth by stimulating their proliferation and migration. PLGF binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. Whereas the three forms are present in most placental tissues, PIGF-2 is specific to early (8 week) placenta and only PIGF-1 is found in the colon and mammary carcinomas.

Alternate Names: Placenta growth factor, PIGF, PGFL, PLGF, PGF

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P49763

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLGF.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.1 mg/ml BSA, 25% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.