PLGF polyclonal, anti-human, mouse, rat
€422.00
In stock
SKU
250824
Catalog Nr.: 250824
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
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Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: CAM Ligands, Cytokines
Pathway and Disease: Cancers, Cell Communication, Signal Transduction, Signaling Molecules and Interaction
Description:
Placenta growth factor (PLGF or PIGF) is a dimeric glycoprotein showing the highest degree of sequence similarity to the vascular endothial growth factor. Alternative splicing of the PLGF primary transcript gives rise to three forms named PIGF-1, 2 and 3, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. PLGF is active in angiogenesis and endothelial cell growth by stimulating their proliferation and migration. PLGF binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. Whereas the three forms are present in most placental tissues, PIGF-2 is specific to early (8 week) placenta and only PIGF-1 is found in the colon and mammary carcinomas.
Alternate Names: Placenta growth factor, PIGF, PGFL, PLGF, PGF
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P49763
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLGF.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A and immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wu MY et al. 2013. European Journal of Pharmacology. doi: 10.1016/j.ejphar.2013.07.010. PMID# 23872401.
[2] Tu H et al. 2013. Journal of Cellular Physiology. Research Article. 228(5):983-990. PMID# 23042533.
[3] Bagley R et al. 2011. Clin Cancer Res. 17:976-988. PMID# 21343374.
Pathway and Disease: Cancers, Cell Communication, Signal Transduction, Signaling Molecules and Interaction
Description:
Placenta growth factor (PLGF or PIGF) is a dimeric glycoprotein showing the highest degree of sequence similarity to the vascular endothial growth factor. Alternative splicing of the PLGF primary transcript gives rise to three forms named PIGF-1, 2 and 3, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. PLGF is active in angiogenesis and endothelial cell growth by stimulating their proliferation and migration. PLGF binds to receptor VEGFR-1/FLT1. PLGF-2 binds neuropilin-1 and 2 in a heparin-dependent manner. Whereas the three forms are present in most placental tissues, PIGF-2 is specific to early (8 week) placenta and only PIGF-1 is found in the colon and mammary carcinomas.
Alternate Names: Placenta growth factor, PIGF, PGFL, PLGF, PGF
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P49763
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PLGF.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A and immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Wu MY et al. 2013. European Journal of Pharmacology. doi: 10.1016/j.ejphar.2013.07.010. PMID# 23872401.
[2] Tu H et al. 2013. Journal of Cellular Physiology. Research Article. 228(5):983-990. PMID# 23042533.
[3] Bagley R et al. 2011. Clin Cancer Res. 17:976-988. PMID# 21343374.
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