PLK3 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis.

Synonyms: CNK, FNK, PLK-3, PRK

Cellular Location: Cytoplasm Golgi apparatus Nucleus centrosome cytoskeleton microtubule organizing center nucleolus

Immunogen:
Recombinant protein of human PLK3

Gene Symbol: PLK3

Gene ID: 1263

Swiss prot: Q9H4B4

Calculated MW: 72kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.