PLOD1 polyclonal, anti-human, mouse

Background:
Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms: EDS6, LH, LH1, LLH, PLOD

Cellular Location: Lumenal side Peripheral membrane protein Rough endoplasmic reticulum membrane

Immunogen:
Recombinant protein of human PLOD1

Gene Symbol: PLOD1

Gene ID: 5351

Swiss prot: Q02809

Calculated MW: 84kDa

Recommended dilution:
WB 1:500-2000, IF 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.