PLP [139-151] Peptide
€144.00
In stock
SKU
350349
Protein Family: Receptors and Channels
Pathway and Disease: Nervous and Sensory Systems
Alternate Names: Myelin Proteolipid protein; PLP; Lipophilin; PLP1; PLP
Accession No.: P60201
Description:
The PLP [139-151] peptide from the myelin proteolipid protein (PLP) has been found to be highly immunogenic in inducing experimental allergic encephalomyelitis (EAE) in SJC/J (H-2s) mice as part of an autoimmune response. The sequence is derived from PLP with a cysteine residue replaced by a serine. The peptide is conserved in mouse, rat, monkey, dog, pig, bovine and found to be similar in chicken, frog, turtle except for the first two residues. Mouse T-cell clones that are reactive with the peptide have been developped, and variations on the different clones' ability to elicit the immune response have been used to understand mechanisms of T-cell function. Later work has devised analogs of this peptide that block the immune response in vitro and in vivo, with implications for the regulation of autoimmune diseases.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1521.7 g/mol
Sequence:
Human: H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH or H-HSLGKWLGHPDKF-OH
Composition:
C72H104N20O17
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Nervous and Sensory Systems
Alternate Names: Myelin Proteolipid protein; PLP; Lipophilin; PLP1; PLP
Accession No.: P60201
Description:
The PLP [139-151] peptide from the myelin proteolipid protein (PLP) has been found to be highly immunogenic in inducing experimental allergic encephalomyelitis (EAE) in SJC/J (H-2s) mice as part of an autoimmune response. The sequence is derived from PLP with a cysteine residue replaced by a serine. The peptide is conserved in mouse, rat, monkey, dog, pig, bovine and found to be similar in chicken, frog, turtle except for the first two residues. Mouse T-cell clones that are reactive with the peptide have been developped, and variations on the different clones' ability to elicit the immune response have been used to understand mechanisms of T-cell function. Later work has devised analogs of this peptide that block the immune response in vitro and in vivo, with implications for the regulation of autoimmune diseases.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1521.7 g/mol
Sequence:
Human: H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH or H-HSLGKWLGHPDKF-OH
Composition:
C72H104N20O17
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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