PLXDC1 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61057
Background:
Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
Alternative Name:
Plexin domain-containing protein 1, Tumor endothelial marker 3, Tumor endothelial marker 7, PLXDC1, TEM3, TEM7
Application Dilution: WB: 1:500~1:1000
Specificity: PLXDC1 polyclonal antibody detects endogenous levels of PLXDC1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PLXDC1.
MW: ~ 56 kDa
Swis Prot.: Q8IUK5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tumor endothelial markers (TEMs) are abundantly expressed in the blood vessels of human solid tumors during angiogenesis and neoangiogensis. These include TEM1 (endosialin), TEM5 (G-protein coupled receptor 124) and TEM7 (plexin domain containing 1). TEMs are associated with the cell surface membrane at low levels in normal human and mouse tissues. TEM5 is a seven-pass transmembrane receptor, whereas TEM1, TEM7 and TEM8 span the membrane once. TEM5 expression is elevated during tumor angiogenesis and neoangiogenesis. TEM7 is highly expressed in tumor endothelium and neurons. Therefore, TEM5 and TEM7 may be suitable targets for the development of antiangiogenic therapies.
Alternative Name:
Plexin domain-containing protein 1, Tumor endothelial marker 3, Tumor endothelial marker 7, PLXDC1, TEM3, TEM7
Application Dilution: WB: 1:500~1:1000
Specificity: PLXDC1 polyclonal antibody detects endogenous levels of PLXDC1 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PLXDC1.
MW: ~ 56 kDa
Swis Prot.: Q8IUK5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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