PML antibody (clone 1D12), anti-human, rat
€435.00
In stock
SKU
AC-AT3354a
Catalog Number: AC-AT3354a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT3354a-PML-Antibody-monoclonal-M02">Request Information AC-AT3354a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IF, Ehttps://www.abcepta.com/products/pdf_download/AT3354a-PML-Antibody-monoclonal-M02">Request Information AC-AT3354a">Request Information
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, PML, MYL, PP8675, RNF71, TRIM19
Antigen Type:
Recombinant Protein
Gene Name: PML
Gene ID: 5371
NCBI Accession: NP_002666.1;NP_150241.2;NP_150242.1;NP_150243.2;NP_150247.2;NP_150249.1;NP_150250.2;NP_150252.1;NP_150253.2
Primary Accession: P29590
Other Accession: BC000080
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19, PML, MYL, PP8675, RNF71, TRIM19
Antigen Type:
Recombinant Protein
Gene Name: PML
Gene ID: 5371
NCBI Accession: NP_002666.1;NP_150241.2;NP_150242.1;NP_150243.2;NP_150247.2;NP_150249.1;NP_150250.2;NP_150252.1;NP_150253.2
Primary Accession: P29590
Other Accession: BC000080
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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