PML Polyclonal Antibody

Background:
promyelocytic leukemia(PML) Homo sapiens The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Alternative Names:
PML, MYL, RNF71, TRIM19, Protein PML, Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19

Immunogen: The antiserum was produced against synthesized peptide derived from human PML. AA range:11-60

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 98

GeneID: PML

Storage: -20°C/1 year

NOTE: For Research Use Only