PMS2 rabbit polyclonal, anti-human

Backgroud: Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

Synonyms: DNA mismatch repair gene, DNA mismatch repair protein PMS2, HNPCC4, PMS1 protein homolog 2

Gene Name: PMS2

Gene ID: 5395

SwissProt ID: P54278

Purification: Affinity Chromatography

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.