PNMA1 antibody (clone 4G6), anti-human, mouse
€435.00
In stock
SKU
AC-AT3360a
Catalog Number: AC-AT3360a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, Ehttps://www.abcepta.com/products/pdf_download/AT3360a-PNMA1-Antibody-monoclonal-M01">Request Information AC-AT3360a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, Ehttps://www.abcepta.com/products/pdf_download/AT3360a-PNMA1-Antibody-monoclonal-M01">Request Information AC-AT3360a">Request Information
Background:
The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.
Other Names:
Paraneoplastic antigen Ma1, 37 kDa neuronal protein, Neuron- and testis-specific protein 1, PNMA1, MA1
Antigen Type:
Recombinant Protein
Gene Name: PNMA1
Gene ID: 9240
NCBI Accession: NP_006020.4
Primary Accession: Q8ND90
Other Accession: NM_006029
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.
Other Names:
Paraneoplastic antigen Ma1, 37 kDa neuronal protein, Neuron- and testis-specific protein 1, PNMA1, MA1
Antigen Type:
Recombinant Protein
Gene Name: PNMA1
Gene ID: 9240
NCBI Accession: NP_006020.4
Primary Accession: Q8ND90
Other Accession: NM_006029
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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