PNOC Polyclonal Antibody

Background:
Nociception, a pain response mechanism, occurs in response to stimuli that threaten the integrity of an organism. The first synapses produced as a result of the initiation of nociception are modulated by excitatory amino acids (glutamate and aspartate) and many peptides (substance P, CGRP, CCK, endogenous opioids). Nociceptin (also designated orphanin FQ) is a neuronal peptide that is similar to opioid peptides. Nociceptin activates KOR-3 (kappa-type opioid receptor, also designated ORL1), a G protein-coupled receptor. Although similar to dynorphin A, a kappa opioid peptide, nociceptin functions to make animals hyperreactive to nociceptive stimulations. Nociceptin is also involved in locomotor behavior and may be involved in the modulation of synaptic plasticity in learning and memory.

Research Area: Neuroscience

Synonyms:
N/OFQ, N23K, N23K/N27K, Nociceptin, included, nocistatin, Npnc1, OFQ, OFQ/N, Orphanin FQ, Orphanin FQ2, Pnoc, PNOC, ppN/OFQ, PPNOC, pre-pro-N/OFQ, prepronociceptin, pronociceptin, Propronociceptin

Immunogen: Synthetic peptide of human PNOC

Swissprot: Q13519
Gene Accession: NP_006219

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-9763/sc-9764/sc-33600