PNPLA2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7989
Background:
The Adiponutrin family members, which have been implicated in obesity and diabetes, consist of Adiponutrin (ADPN), GS1, GS2, GS2-like, PNPLA1, and adipose triglyceride lipase (ATGL), also designated Desnutrin or Patatin-like phospholipase domain-containing protein 2 (PLNPA2). AGTL is a 486-amino acid protein that is highly expressed in mouse and human adipose tissue. It contains a highly conserved 180-amino acid N-terminal patatin domain common to plant acyl-hydrolases with a glycine-rich region, an aspartate active site motif, and an active serine hydrolase motif. Along with hormone-sensitive lipase, ATGL catabolizes stored triglycerides in mammalian adipose tissue. The lipase activity of AGTL is dependent upon the presence of an activated serine residue. ADPN and ATGL are oppositely regulated by insulin, where upregulation of ATGl and downregulation of ADPN occurs when fasting.
Alternative Name:
Adipose triglyceride lipase, ATGL, ATGL DESNUTRIN, Calcium independent phospholipase A2, Calcium-independent phospholipase A2, Desnutrin, FP17548, IPLA2 zeta, IPLA2-zeta, PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2, Patatin-like phospholipase domain-containing protein 2, PEDF R, PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA, Pigment epithelium derived factor, Pigment epithelium-derived factor, plpl, plpl2, PLPL2_HUMAN, Pnpla2, Transport secretion protein 2, Transport secretion protein 2.2, Transport-secretion protein 2, Triglyceride hydrolase, TTS 2.2, TTS2, TTS2.2, ZETA,
Application Dilution: WB: 1:500 - 1:2000
Specificity: PNPLA2 polyclonal antibody detects endogenous levels of PNPLA2 protein.
Immunogen:
Recombinant full length Human PNPLA2.
MW: ~ 55 kDa
Swis Prot.: Q96AD5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Adiponutrin family members, which have been implicated in obesity and diabetes, consist of Adiponutrin (ADPN), GS1, GS2, GS2-like, PNPLA1, and adipose triglyceride lipase (ATGL), also designated Desnutrin or Patatin-like phospholipase domain-containing protein 2 (PLNPA2). AGTL is a 486-amino acid protein that is highly expressed in mouse and human adipose tissue. It contains a highly conserved 180-amino acid N-terminal patatin domain common to plant acyl-hydrolases with a glycine-rich region, an aspartate active site motif, and an active serine hydrolase motif. Along with hormone-sensitive lipase, ATGL catabolizes stored triglycerides in mammalian adipose tissue. The lipase activity of AGTL is dependent upon the presence of an activated serine residue. ADPN and ATGL are oppositely regulated by insulin, where upregulation of ATGl and downregulation of ADPN occurs when fasting.
Alternative Name:
Adipose triglyceride lipase, ATGL, ATGL DESNUTRIN, Calcium independent phospholipase A2, Calcium-independent phospholipase A2, Desnutrin, FP17548, IPLA2 zeta, IPLA2-zeta, PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2, Patatin-like phospholipase domain-containing protein 2, PEDF R, PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA, Pigment epithelium derived factor, Pigment epithelium-derived factor, plpl, plpl2, PLPL2_HUMAN, Pnpla2, Transport secretion protein 2, Transport secretion protein 2.2, Transport-secretion protein 2, Triglyceride hydrolase, TTS 2.2, TTS2, TTS2.2, ZETA,
Application Dilution: WB: 1:500 - 1:2000
Specificity: PNPLA2 polyclonal antibody detects endogenous levels of PNPLA2 protein.
Immunogen:
Recombinant full length Human PNPLA2.
MW: ~ 55 kDa
Swis Prot.: Q96AD5
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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