PNPO Polyclonal Antibody

Background:
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

Research Area: Metabolism, Neuroscience, Signal transduction

Synonyms:
EC 1.4.3.5, FLJ10535, PDXPO, PNPO, PNPO, Pyridoxal 5' phosphate synthase, pyridoxamine 5' phosphate oxidase, Pyridoxamine phosphate oxidase , Pyridoxamine-phosphate oxidase, pyridoxine 5' phosphate oxidase, Pyridoxine-5'-phosphate oxidase

Immunogen: Synthetic peptide of human PNPO

Swissprot: Q9NVS9
Gene Accession: NP060599

Calculated MW: 30 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:20-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.