PNRC2 Polyclonal Antibody

Background:
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
0610011E17Rik, D4Bwg0593e, FLJ20312, MGC11707, MGC93828, MGC99541, OTTMUSP00000010360, OTTMUSP00000010366, pnrc2, PNRC2, Proline rich nuclear receptor coactivator 2, Proline-rich nuclear receptor coactivator 2, RP11-4M23.5, RP23-161N17.3

Immunogen: Fusion protein of human PNRC2

Swissprot: Q9NPJ4
Gene Accession: BC001959

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.84 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.