Podocalyxin (PODXL) [clone EP248], anti-human

Description: Podocalyxin-like 1 (PODXL) is an anti-adhesive transmembrane protein belonging to the CD34 family of sialomucins. Podocalyxin-like 1 inhibits cell–cell interaction through charge-repulsive effects, and functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte. PODXL is primarily expressed in vascular endothelial cells. A high level of expression has been found in kidney podocytes. Overexpression of PODXL associated with poor prognosis has been found in several types of malignancies including cancers of the breast, prostate, and colon and malignant astrocytoma.Localization: cytoplasm, membraneDilution: 50-200Positive Control: breast ca, kidneyHIER: EDTA pH8.0Status: RUO