POLD2 Polyclonal Antibody

Background:
This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
DNA polymerase delta subunit 2, DNA polymerase delta subunit p50, DNA polymerase subunit delta 2, DNA polymerase subunit delta p50, DPOD2, POLD 2, pold2

Immunogen: Fusion protein of human POLD2

Swissprot: P49005
Gene Accession: BC000459

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.68 mg/mL
Dilution: IHC 1:50-1:300, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.