POLG polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP14948B
Catalog Number: AC-AP14948B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34378
Applications: IF, FC, WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34378
Applications: IF, FC, WB, IHC-P
Datasheet
Request Information
Background:
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Other Names:
DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA
Target/Specificity:
This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.
Antigen Region:
1120-1148
Antigen Type: Synthetic Peptide
Gene Name: POLG {ECO:0000303|PubMed:10827171, ECO:0000312|HGNC:HGNC:9179}
Gene ID: 5428
Primary Accession: P54098
NCBI Accession: NP_001119603.1;NP_002684.1
Other Accession: Q9QYV8; P54099; NP_001119603.1; NP_002684.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
Other Names:
DNA polymerase subunit gamma-1, Mitochondrial DNA polymerase catalytic subunit, PolG-alpha, POLG, MDP1, POLG1, POLGA
Target/Specificity:
This POLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1120-1148 amino acids from the C-terminal region of human POLG.
Antigen Region:
1120-1148
Antigen Type: Synthetic Peptide
Gene Name: POLG {ECO:0000303|PubMed:10827171, ECO:0000312|HGNC:HGNC:9179}
Gene ID: 5428
Primary Accession: P54098
NCBI Accession: NP_001119603.1;NP_002684.1
Other Accession: Q9QYV8; P54099; NP_001119603.1; NP_002684.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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