POLI polyclonal (C-term), anti-human
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In stock
SKU
AC-AP14526b
Catalog Number: AC-AP14526b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34404
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34404
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Other Names:
DNA polymerase iota, Eta2, RAD30 homolog B, POLI, RAD30B
Target/Specificity:
This POLI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-701 amino acids from the C-terminal region of human POLI.
Antigen Region:
673-701
Antigen Type: Synthetic Peptide
Gene Name: POLI
Gene ID: 11201
Primary Accession: Q9UNA4
NCBI Accession: NP_009126.2
Other Accession: NP_009126.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Other Names:
DNA polymerase iota, Eta2, RAD30 homolog B, POLI, RAD30B
Target/Specificity:
This POLI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 673-701 amino acids from the C-terminal region of human POLI.
Antigen Region:
673-701
Antigen Type: Synthetic Peptide
Gene Name: POLI
Gene ID: 11201
Primary Accession: Q9UNA4
NCBI Accession: NP_009126.2
Other Accession: NP_009126.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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