POLK antibody (clone 6F2), anti-human
€435.00
In stock
SKU
AC-AT3371a
Catalog Number: AC-AT3371a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT3371a">Request Information
Background:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).
Other Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Antigen Type:
Recombinant Protein
Gene Name: POLK
Gene ID: 51426
NCBI Accession: NP_057302.1
Primary Accession: Q9UBT6
Other Accession: BC050718
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).
Other Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Antigen Type:
Recombinant Protein
Gene Name: POLK
Gene ID: 51426
NCBI Accession: NP_057302.1
Primary Accession: Q9UBT6
Other Accession: BC050718
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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