POLK Blocking Peptide (Center)

Background:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).

Other Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1

Target/Specificity:
The synthetic peptide sequence is selected from aa 546-560 of HUMAN POLK

Gene Name: POLK

Gene ID: 51426
Primary Accession: Q9UBT6
Other Accession: NP_057302.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.