POLK polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP19981c
Catalog Number: AC-AP19981c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB41936
Applications: WB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB41936
Applications: WB
Datasheet
Request Information
Background:
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).
Other Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Target/Specificity:
This POLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the Central region of human POLK.
Antigen Region:
531-560
Antigen Type: Synthetic Peptide
Gene Name: POLK
Gene ID: 51426
Primary Accession: Q9UBT6
NCBI Accession: NP_057302.1
Other Accession: NP_057302.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).
Other Names:
DNA polymerase kappa, DINB protein, DINP, POLK, DINB1
Target/Specificity:
This POLK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 531-560 amino acids from the Central region of human POLK.
Antigen Region:
531-560
Antigen Type: Synthetic Peptide
Gene Name: POLK
Gene ID: 51426
Primary Accession: Q9UBT6
NCBI Accession: NP_057302.1
Other Accession: NP_057302.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review