POLR2A Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6821a
Background:
POLR2A is the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This protein contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Other Names:
DNA-directed RNA polymerase II subunit RPB1, RNA polymerase II subunit B1, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA-directed RNA polymerase II subunit RPB1, POLR2A, POLR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6821a was selected from the N-term region of human POLR2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: POLR2A (HGNC:9187)
Gene ID: 5430
Primary Accession: P24928
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
POLR2A is the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This protein contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
Other Names:
DNA-directed RNA polymerase II subunit RPB1, RNA polymerase II subunit B1, DNA-directed RNA polymerase II subunit A, DNA-directed RNA polymerase III largest subunit, RNA-directed RNA polymerase II subunit RPB1, POLR2A, POLR2
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6821a was selected from the N-term region of human POLR2A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: POLR2A (HGNC:9187)
Gene ID: 5430
Primary Accession: P24928
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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