Polycomb complex protein BMI-1 (clone P9), anti-human, mouse, rat
€0.00
In stock
SKU
BMA1036
Catalog Number: BMA1036
Size: 100 μg
Isotype: Mouse IgG2a
Reactivity: human, mouse, rat
Application(s): WB, IHC-P, ICC, Flow-Cyt
Request Information
Size: 100 μg
Isotype: Mouse IgG2a
Reactivity: human, mouse, rat
Application(s): WB, IHC-P, ICC, Flow-Cyt
Request Information
Background:
BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. It is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.[1] BMI1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells.[2] BMI1 is also thought to inhibit ageing in neurons through the suppression of p53.[3]
Immunogen:
Recombinant protein within human Bmi1 full sequence.
Recommended Application:
Western Blot, WB(1:500); Immunohistochemistry, IHC-P (1:100); Immunocytochemistry, ICC (1:100); Flow Cytometry, Flow-Cyt (1:50-1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. It is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development.[1] BMI1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells.[2] BMI1 is also thought to inhibit ageing in neurons through the suppression of p53.[3]
Immunogen:
Recombinant protein within human Bmi1 full sequence.
Recommended Application:
Western Blot, WB(1:500); Immunohistochemistry, IHC-P (1:100); Immunocytochemistry, ICC (1:100); Flow Cytometry, Flow-Cyt (1:50-1:100)
Product Form: Liquid
Purification: Protein A purified
Storage Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol and 0.05% Sodium Azide.
Storage Instruction:
Store at 4℃ after thawing (1 week). Aliquot and store at -20℃ for long term (at least one year). Avoid repeated freeze and thaw cycles.
| Is Featured? | No |
|---|
Write Your Own Review