Polycystin 1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Polycystin-1 is a protein that in humans is encoded by the PKD1 gene. This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described.

Description:
Rabbit IgG polyclonal antibody for Polycystin-1 (PKD1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Autosomal dominant polycystic kidney disease 1 protein antibody, Autosomal dominant polycystic kidney disease protein 1 antibody, nPKC-D1 antibody, nPKC-mu antibody, OTTHUMP00000208669 antibody, OTTHUMP00000208670 antibody, PBP antibody, Pc-1 antibody, PKD antibody, Pkd1 antibody, PKD1_HUMAN antibody, Polycystic Kidney Disease 1 antibody, polycystic kidney disease-associated protein antibody, Polycystin 1 Precursor antibody, Polycystin-1 antibody, Protein kinase C mu type antibody, Protein kinase D antibody, Serine/threonine-protein kinase D1 antibody, transient receptor potential cation channel, subfamily P, member 1 antibody, TRPP1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human Polycystin 1 (4214-4250aa RLQAVFEALLTQFDRLNQATEDVYQLEQQLHSLQGRR), different from the related mouse sequence by six amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.