PP2B-A alpha Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.|cofactor:Binds 1 Fe(3+) ion per subunit.|cofactor:Binds 1 zinc ion per subunit.|Calcium-dependent| calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.|online information:Calcineurin entry|Belongs to the PPP phosphatase family.|Belongs to the PPP phosphatase family. PP-2B subfamily.|subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.|subunit:Composed of two components (A and B)| the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2| MYOZ1| MYOZ2 and MYOZ3.|

Research Area: Immunology, Signal transduction

Synonyms: PP2B-Aα, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, EC 3.1.3.16, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year