PP6C polyclonal, anti-human, mouse, rat
€469.00
In stock
SKU
252096
Protein Family: Enzymes
Pathway and Disease: Cell Growth and Death
Description:
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C A) is the catalytic subunit of protein phospatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. The N-terminal domain of PP6C A restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. PP6C A downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. PP6C A is ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
Alternate Names: Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, PPP6C, PPP6
Application Notes: E: 1:10,000-1:50,000; WB: 1:500-1:2,000
Accession No.: O00743
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PPP6C.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cell Growth and Death
Description:
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C A) is the catalytic subunit of protein phospatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. The N-terminal domain of PP6C A restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. PP6C A downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. PP6C A is ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.
Alternate Names: Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, PPP6C, PPP6
Application Notes: E: 1:10,000-1:50,000; WB: 1:500-1:2,000
Accession No.: O00743
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PPP6C.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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