PPA1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6699
Background:
PPA1 (Pyrophosphate phospho-hydrolase 1), also known as IOPPP (inorganic pyrophosphatase), PP1, PP or PPase, belongs to the PPase family of inorganic pyrophosphatases. Inorganic pyrophosphatases catalyze the intracellular conversion of pyrophosphate to inorganic phosphate, a key reaction for phosphate metabolism in cells. PPA1 is a ubiquitously expressed protein that localizes to the cytoplasm and is required for cell growth. It exists as a homodimer exhibiting magnesium dependent activity. The binding of two magnesium ions is required to stimulate PPA1 activity; however, both subunits in the homodimer are capable of binding four magnesium ions. The additional ions are useful in forming complexes with substrates and products. In addition, the activity of PPA1 can be inhibited by calcium.
Alternative Name:
Inorganic pyrophosphatase, IOPPP, IPYR, PPA1, PPase, Pyp, Pyrophosphate phospho hydrolase, Pyrophosphate phospho-hydrolase,
Application Dilution: WB: 1:500~1:2000
Specificity: PPA1 polyclonal antibody detects endogenous levels of PPA1 protein.
Immunogen:
Recombinant full length Human PPA1.
MW: ~ 32 kDa
Swis Prot.: Q15181
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PPA1 (Pyrophosphate phospho-hydrolase 1), also known as IOPPP (inorganic pyrophosphatase), PP1, PP or PPase, belongs to the PPase family of inorganic pyrophosphatases. Inorganic pyrophosphatases catalyze the intracellular conversion of pyrophosphate to inorganic phosphate, a key reaction for phosphate metabolism in cells. PPA1 is a ubiquitously expressed protein that localizes to the cytoplasm and is required for cell growth. It exists as a homodimer exhibiting magnesium dependent activity. The binding of two magnesium ions is required to stimulate PPA1 activity; however, both subunits in the homodimer are capable of binding four magnesium ions. The additional ions are useful in forming complexes with substrates and products. In addition, the activity of PPA1 can be inhibited by calcium.
Alternative Name:
Inorganic pyrophosphatase, IOPPP, IPYR, PPA1, PPase, Pyp, Pyrophosphate phospho hydrolase, Pyrophosphate phospho-hydrolase,
Application Dilution: WB: 1:500~1:2000
Specificity: PPA1 polyclonal antibody detects endogenous levels of PPA1 protein.
Immunogen:
Recombinant full length Human PPA1.
MW: ~ 32 kDa
Swis Prot.: Q15181
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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