PPAR-γ (C-terminus) (clone ), anti-human
€388.00
In stock
SKU
MB0080
Background:
PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Alternative Name:
Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR γ, PPARγ
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of PPAR gamma (C-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to amino acids C-terminus of Human PPAR-γ.
MW: Predicted band size: 54KDa , Observed band size: 54KD
Swis Prot.: P37231
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.
Alternative Name:
Peroxisome proliferator-activated receptor gamma, Short name=PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3, PPAR γ, PPARγ
Application Dilution: WB: 1:1000
Specificity: This antibody detects endogenous levels of PPAR gamma (C-terminus) and does not cross-react with related proteins
Immunogen:
Synthetic peptide, corresponding to amino acids C-terminus of Human PPAR-γ.
MW: Predicted band size: 54KDa , Observed band size: 54KD
Swis Prot.: P37231
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
| Is Featured? | No |
|---|
Write Your Own Review