PPARA Polyclonal Antibody

Background:
Peroxisome proliferator-activated receptor alpha (PPARA) is a ligand-activated transcription factor that belongs to the PPAR nuclear receptor superfamily. PPARA is essential in the modulation of lipid transport and metabolism, mainly through activating mitochondrial and peroxisomal fatty acid β-oxidation pathways. In addition, PPARA seems to decrease inflammation mainly through direct interaction with NF-κB, causing inhibition of its signaling pathway or reducing the activated levels of NF-κB and subsequent inflammation. Furthermore, PPARA was implicated in the attenuation of oxidative stress in alcoholic liver disease when treated with polyenephosphatidylcholine through downregulation of ROS-generating enzymes such as ethanol-inducible cytochrome P450 2E1 (CYP2E1), acyl-CoA oxidase, and NADPH oxidase.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction

Synonyms:
hPPAR, MGC2237, MGC2452, NR1C1, Nuclear receptor subfamily 1 group C member 1, OTTHUMP00000197740, OTTHUMP00000197741, Peroxisome proliferative activated receptor alpha, Peroxisome proliferator activated receptor alpha, Peroxisome proliferator-activated receptor alpha, PPAR, PPAR-alpha, ppara, PPARA, PPARalpha

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse PPARα

Swissprot: P23204,P37230

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:200-1:500

Storage:
Store at -20°C. Avoid freeze / thaw cycles.