PPARD Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13778b
Background:
This gene encodes a member of the peroxisomeproliferator-activated receptor (PPAR) family. PPARs are nuclearhormone receptors that bind peroxisome proliferators and controlthe size and number of peroxisomes produced by cells. PPARs mediatea variety of biological processes, and may be involved in thedevelopment of several chronic diseases, including diabetes,obesity, atherosclerosis, and cancer. This protein is a potentinhibitor of ligand-induced transcription activity of PPAR alphaand PPAR gamma. It may function as an integrator of transcriptionrepression and nuclear receptor signaling. The expression of thisgene is found to be elevated in colorectal cancer cells. Theelevated expression can be repressed by adenomatosis polyposis coli(APC), a tumor suppressor protein related to APC/beta-cateninsignaling pathway. Knockout studies in mice suggested the role ofthis protein in myelination of the corpus callosum, lipidmetabolism, and epidermal cell proliferation. Alternate splicingresults in multiple transcript variants.
Other Names:
Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13778b was selected from the C-term region of PPARD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PPARD (HGNC:9235)
Gene ID: 5467
Primary Accession: Q03181
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the peroxisomeproliferator-activated receptor (PPAR) family. PPARs are nuclearhormone receptors that bind peroxisome proliferators and controlthe size and number of peroxisomes produced by cells. PPARs mediatea variety of biological processes, and may be involved in thedevelopment of several chronic diseases, including diabetes,obesity, atherosclerosis, and cancer. This protein is a potentinhibitor of ligand-induced transcription activity of PPAR alphaand PPAR gamma. It may function as an integrator of transcriptionrepression and nuclear receptor signaling. The expression of thisgene is found to be elevated in colorectal cancer cells. Theelevated expression can be repressed by adenomatosis polyposis coli(APC), a tumor suppressor protein related to APC/beta-cateninsignaling pathway. Knockout studies in mice suggested the role ofthis protein in myelination of the corpus callosum, lipidmetabolism, and epidermal cell proliferation. Alternate splicingresults in multiple transcript variants.
Other Names:
Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13778b was selected from the C-term region of PPARD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: PPARD (HGNC:9235)
Gene ID: 5467
Primary Accession: Q03181
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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