PPARG (clone 3A4A9, 1E6A1), anti-human
€478.00
In stock
SKU
252786
Protein Family: Receptors and Channels, Transcription Factors
Pathway and Disease: Cancers, Carbohydrate Metabolism, Endocrine System, Lipid Metabolism, Metabolic Disorders, Transcription
Description:
PPAR-gamma (Peroxisome proliferator-activated receptor gamma) is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, PPAR-gamma binds to a promoter element in the gene for acyl-CoA oxidase and activates transcription. PPAR-gamma controls the peroxisomal beta-oxidation pathway of fatty acid and is a key regulator of adipocyte differentiation and glucose homeostasis. PPAR-gamma forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6, which leads to a high transcriptional activity. Defects in PPAR-gamma are the cause of familial partial lipodystrophy type 3, a marked loss of subcutaneous fat from the extremities. Defects in PPAR-gamma are also associated with type 2 insulin-resistant diabetes, hypertension, obesity and colon cancer.
Alternate Names: Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3
Application Notes: WB: 1:500-1:2000
Accession No.: P37231
Antigen: Purified recombinant fragment of PPARG(aa170-270) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Carbohydrate Metabolism, Endocrine System, Lipid Metabolism, Metabolic Disorders, Transcription
Description:
PPAR-gamma (Peroxisome proliferator-activated receptor gamma) is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, PPAR-gamma binds to a promoter element in the gene for acyl-CoA oxidase and activates transcription. PPAR-gamma controls the peroxisomal beta-oxidation pathway of fatty acid and is a key regulator of adipocyte differentiation and glucose homeostasis. PPAR-gamma forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6, which leads to a high transcriptional activity. Defects in PPAR-gamma are the cause of familial partial lipodystrophy type 3, a marked loss of subcutaneous fat from the extremities. Defects in PPAR-gamma are also associated with type 2 insulin-resistant diabetes, hypertension, obesity and colon cancer.
Alternate Names: Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3
Application Notes: WB: 1:500-1:2000
Accession No.: P37231
Antigen: Purified recombinant fragment of PPARG(aa170-270) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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