PPARG Polyclonal Antibody

Background:
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

Research Area: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Stem Cells

Synonyms:
CIMT1, GLM1, NR1C3, Nuclear receptor subfamily 1 group C member 3, OTTHUMP00000185032, OTTHUMP00000185036, Peroxisome proliferator activated nuclear receptor gamma variant 1, Peroxisome proliferator activated receptor gamma 1, Peroxisome Proliferator Activated Receptor gamma, Peroxisome proliferator-activated receptor gamma, PPAR gamma, PPAR-gamma, PPARG, PPARG, PPARG1, PPARG2, PPARgamma

Immunogen: Recombinant protein corresponding to Mouse PPARγ

Swissprot: P37231,P37238,O88275

Calculated MW: 58Da
Observed MW: 50-60 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Concentration: 0.58 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S0898656818301724
https://pubmed.ncbi.nlm.nih.gov/29287795/
https://pubmed.ncbi.nlm.nih.gov/31472955/
https://pubmed.ncbi.nlm.nih.gov/31999897/
https://pubmed.ncbi.nlm.nih.gov/32755726/